Evidence map›Paper›PMID 41840915›Full record

ArticleGenesis (New York, N.Y. : 2000)2026

Generation of a Novel Col8a2

Yong Yuan, Josiah Holt, Samuel Lorry, Yen-Chiao Wang, Yueh-Chiang Hu, Zhixing Ma, Adam Kaufman, Winston Kao, Diego G Ogando, Chia-Yang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yong YuanDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Josiah HoltDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Samuel LorryDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Yen-Chiao WangDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Yueh-Chiang HuCincinnati Children's Hospital, Research Foundation, Cincinnati, Ohio, USA.
Zhixing MaCincinnati Children's Hospital, Research Foundation, Cincinnati, Ohio, USA.
Adam KaufmanDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Winston KaoDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Diego G OgandoSchool of Optometry, Indiana University, Bloomington, Indiana, USA.
Chia-Yang LiuDepartment of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Funding

Molecular mechanism of corneal epithelial stratification and innervationR01EY029071 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2019 to 2022
$2.1M
Smad4 is a master regulator for extracellular matrix homeostasis in the corneal stromaR21EY037000 · NEI · UNIVERSITY OF CINCINNATI · PI CHIA-YANG LIU · 2025 to 2026
$446k
Models of Fuchs Corneal Endothelial DystrophyR21EY036160 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI OGANDO, DIEGO · 2024 to 2025
$436k
NEI NIH HHS R01 EY029071NEI NIH HHS R21 EY036160NEI NIH HHS R21 EY037000
6 · The paper itself

Abstract

The corneal endothelium is a monolayer of specialized cells that maintains stromal deturgescence and transparency, functions essential for vision. Despite its clinical importance, the developmental origins and homeostatic programs of the endothelium remain poorly understood, in part due to the lack of a lineage-specific genetic driver. To overcome this limitation, we generated a Col8a2

Indexed as

Collagen Type VIIIEndothelial CellsEndothelium, CornealFuchs' Endothelial DystrophyAnimalsDescemet MembraneDisease Models, AnimalGene Knock-In TechniquesHumansIntegrasesMiceMice, TransgenicCollagen Type VIIICre recombinaseIntegrasesCol8a2P2A‐CreERT2 mouse modelcorneal endotheliumDescemet's membraneFuchs' endothelial corneal dystrophposterior polymorphous corneal dystrophy

Identifiers

PMID41840915
PMCPMC12993115

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.