Evidence map›Paper›PMID 41841111›Full record

ArticleJournal of clinical biochemistry and nutrition2026

The effect of SIRT1 knockdown on the gene expression of CoQ10 biosynthetic enzymes.

Rena Okuizumi, Satsuki Maruyama, Mizuho Okamoto, Akio Fujisawa, Yorihiro Yamamoto, Misato Kashiba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rena OkuizumiSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Satsuki MaruyamaSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Mizuho OkamotoSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Akio FujisawaSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Yorihiro YamamotoSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.
Misato KashibaSchool of Bionics, Tokyo University of Technology, 1404-1 Katakura-machi, Hachioji, Tokyo 192-0982, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coenzyme Q10 is a lipid-soluble antioxidant essential for the mitochondrial electron transport chain. Its concentration in the body decreases with age. The biosynthesis of coenzyme Q10 involves enzymes coq1 (PDSS1, PDSS2) through coq9, though the regulatory mechanisms of their gene expression and enzyme activities are unknown. SIRT1, an anti-aging gene, regulates various transcription factors. This study investigates the impact of SIRT1 knockdown on the gene expression of coenzyme Q10 biosynthetic enzymes and coenzyme Q10 levels in MDA-MB-231 and HepG2 cells. SIRT1 knockdown significantly increased

Indexed as

coenzyme Q10NRF1PGC-1αsirtuin1

Identifiers

PMID41841111
PMCPMC12989230

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.