Evidence map›Paper›PMID 41843675›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis.

Ziqi Zou, Jiajie Zhou, Yanhua Lu, Yuting Huang, Linru Zhou, Xiaoyu Wang, Jiahui Chen, Hengrui Tian, Xinnuo Ge, Chenyao Guo and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ziqi Zou *Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jiajie Zhou *Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yanhua Lu *Institute of Ageing Research, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Yuting HuangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Linru ZhouInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Xiaoyu WangInstitute of Neuroscience, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Jiahui ChenInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Hengrui TianDepartment of Immunology, School of Basic Medical Science, Henan University, Kaifeng 475004, China.
Xinnuo GeInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chenyao GuoInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Weiran YaoInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Xiaosheng ZhengDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.ORCID 0000-0001-6486-5079
Jia HeInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yue DuInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yiting ZhouKey Laboratory of Multiple Organ Failure (Ministry of Education), Department of Orthopaedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0003-4543-3099
Yinjing SongInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Wei LuoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Qingqing WangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0002-0415-0052
Jun-Ping LiuInstitute of Ageing Research, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.
Meng XiaInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0001-5223-7390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuro-immune crosstalk is increasingly recognized in Parkinson's disease (PD), and ATP13A2 is well known for its neuroprotective role. However, it remains unclear whether

Indexed as

InflammasomesMacrophagesMitochondriaNLR Family, Pyrin Domain-Containing 3 ProteinParkinson DiseaseProton-Translocating ATPasesAnimalsHomeostasisHumansLysosomesMiceMice, Inbred C57BLMutationTHP-1 CellsATP13A2 protein, humanATP13A2 protein, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mouseProton-Translocating ATPasesATP13A2 mutationmacrophageneuroinflammationNLRP3 inflammasomeParkinson’s disease

Identifiers

PMID41843675
PMCPMC13012027

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.