ArticleProceedings of the National Academy of Sciences of the United States of America2026
Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.
Alexandra Lee, Autumn Gentzler, Declan Fitzpatrick, Sithara Raju Ponny, Ozkan Aydemir, Myoung Sook Han, Caroline A Lewis, Guangping Gao, Roger J Davis
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Alexandra LeeProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Autumn GentzlerProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0009-0001-5575-4470 Declan FitzpatrickProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Sithara Raju PonnyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Ozkan AydemirProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-3458-6527 Myoung Sook HanProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Caroline A LewisProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Guangping GaoHorae Gene Therapy Center, Department of Genetic and Cellular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0003-0097-9012 Roger J DavisProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-0130-1652 Funding
Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4MMetabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6MHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK107220HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK112698NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698
6 · The paper itselfAbstract
Indexed as
Alternative SplicingRNA PrecursorsStress, PhysiologicalAnimalsCircadian RhythmExonsHepatocytesLiverMiceMitogen-Activated Protein Kinase 8PhosphorylationRetinoid X Receptor alphaSignal TransductionMitogen-Activated Protein Kinase 8Retinoid X Receptor alphaRNA Precursorsalternative pre-mRNA splicingcircadian rhythmJNKmetabolic stress
Identifiers
PMID41843681
PMCPMC13012108
What Socratic holds
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