ArticleJournal of the American Chemical Society2026
Total Synthesis of the SJG-2 Glycan: General Strategies for Constructing Sterically Congested Sialylated Glycans.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gangliosides are a diverse class of glycosphingolipids whose sialylated glycans regulate processes ranging from neuronal repair to immune responses. Among them, SJG-2, an echinoderm-derived ganglioside with potent neuroregenerative activity, stands out for its rare and highly branched trisialylated glycan motif. The unusual architecture of the heptasaccharide SJG-2 glycan with two terminal sialic acids attached to galactose (Gal) via α(2,3)- and α(2,4)-sialylations and an additional internal β(1,8)-sialylation to another sialic acid has rendered it synthetically inaccessible for over two decades. Here, we report the first total synthesis of the SJG-2 glycan. A conformational inversion strategy using a
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