In one paragraphArticle in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
22 authors.
Kathleen Van DykDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0003-1500-930X Wanting ZhaiDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, United States.
Tim A AhlesDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0002-7936-2818 James C RootDepartment of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States.ORCID 0000-0001-7332-6165 Jaeil AhnDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, United States.ORCID 0000-0001-7998-4759 Ashley L ArteseDepartment of Exercise Science and Health Promotion, Charles E. Schmidt College of Science, Florida Atlantic University, Boca Raton, FL, United States.ORCID 0000-0001-8811-566X Traci N BetheaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States.ORCID 0000-0003-3205-2078 Harvey J CohenCenter for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, United States.
Martine ExtermannSenior Adult Oncology Program, Department of Oncology Sciences, Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.ORCID 0000-0003-4381-1199 Deena GrahamJohn Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, United States.ORCID 0000-0003-1111-6984 Claudine IsaacsDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.ORCID 0000-0002-9646-1260 Heather S L JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.ORCID 0000-0001-7353-3711 Brenna C McDonaldDepartment of Radiology and Imaging Sciences, Melvin and Bren Simon Comprehensive Cancer Center, and Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID 0000-0001-6895-4490 Zev M NakamuraDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.ORCID 0000-0001-9695-1457 Kelly E RentscherDepartment of Psychiatry and Behavioral Medicine, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States.ORCID 0000-0003-1887-3953 Andrew J SaykinDepartment of Radiology and Imaging Sciences, Melvin and Bren Simon Comprehensive Cancer Center, and Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, United States.ORCID 0000-0002-1376-8532 Brent J SmallSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.ORCID 0000-0002-7444-4689 Danielle B TometichDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, United States.ORCID 0000-0002-5939-0635 Xingtao ZhouDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, Washington, DC, United States.ORCID 0000-0002-5164-125X Judith E CarrollDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-5516-0819 Jeanne S MandelblattGeorgetown Lombardi Institute for Cancer and Aging Research (I-CARE), Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC, United States.ORCID 0000-0002-2490-005X Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MBio-behavioral Research At The Intersection of Cancer and AgingR35CA197289 · NCI · GEORGETOWN UNIVERSITY · PI MANDELBLATT, JEANNE · 2015 to 2021
$6.2MSocial Determinants of Health as Transducers of Cellular Aging: A New Multi-level Paradigm to Reduce Survivorship Disparities at the Intersection of Cancer and AgingR35CA283926 · NCI · GEORGETOWN UNIVERSITY · PI Jeanne Mandelblatt · 2023 to 2026
$3.7MPatterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related DementiasR01AG082348 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Judith E Carroll, Jeanne Mandelblatt · 2023 to 2026
$3.3MI-REACH (Infrastructure for REsearch on Cancer and Aging)R33AG075008 · NIA · GEORGETOWN UNIVERSITY · PI Lucile L. Adams-Campbell, Judith E Carroll · 2024 to 2026
$2.3MHeterogeneity in biological, physical, and cognitive aging in older breast cancer survivors and controlsR56AG068086 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARROLL, JUDITH E, MANDELBLATT, JEANNE · 2021 to 2021
$886kCancer-related cognitive impairment: Real-time evaluation and assessment of long-term impact of treatment on young adult survivors (CRCI REALITY)R00CA270294 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Danielle Tometich · 2024 to 2026
$747kAccelerated biological and phenotypic aging in hematopoietic cell transplant survivors: Social support as a protective factorK01AG065485 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RENTSCHER, KELLY E · 2020 to 2024
$600kMemantine and Exercise for Chemotherapy-Related Cognitive Decline in Patients with Breast CancerK23AG086604 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Zev Nakamura · 2024 to 2026
$547kFrank M. Ewing Foundation Endowed Chair of Hematology and OncologyGeorgetown Lombardi Comprehensive Cancer Center for support of the Biostatistics and Bioinformatics Resource and the Non-Therapeutic Shared Resource P30CA008748Georgetown Lombardi Comprehensive Cancer Center for support of the Biostatistics and Bioinformatics Resource and the Non-Therapeutic Shared Resource R01CA172119Georgetown Lombardi Comprehensive Cancer Center for support of the Biostatistics and Bioinformatics Resource and the Non-Therapeutic Shared Resource R01CA237535Georgetown Lombardi Comprehensive Cancer Center for support of the Biostatistics and Bioinformatics Resource and the Non-Therapeutic Shared Resource R01CA244673Georgetown Lombardi Comprehensive Cancer Center for support of the Biostatistics and Bioinformatics Resource and the Non-Therapeutic Shared Resource U54CA137788National Cancer Institute at the National Institutes of Health K08CA241337National Cancer Institute at the National Institutes of Health P30CA51008National Cancer Institute at the National Institutes of Health R01CA129769National Cancer Institute at the National Institutes of Health R35CA197289National Cancer Institute at the National Institutes of Health R35CA283926NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA270294NCI NIH HHS R35 CA197289NCI NIH HHS R35 CA283926NIA NIH HHS K01 AG065485NIA NIH HHS K01AG065485NIA NIH HHS K23AG086604NIA NIH HHS P30AG010133NIA NIH HHS P30 AG072976NIA NIH HHS P30AG072976NIA NIH HHS R01 AG082348NIA NIH HHS R01AG082348NIA NIH HHS R33AG075008NIA NIH HHS R56AG068086Thinking and Living cohort
6 · The paper itselfAbstract
Cognitive effects of breast cancer antiestrogen endocrine therapy are a salient concern for survivors, given the growing evidence that estrogen plays a role in late-life dementia risk. The APOE4 genotype has been linked with risk for cognitive difficulties, studied mainly in younger cancer survivors. We found that women aged 60+ with nonmetastatic breast cancer enrolled in the prospective Thinking and Living with Cancer study who underwent endocrine therapy had lower subjective (P = .06) and objective (P = .08) cognitive function than frequency-matched controls across time. At 5 years, however, women with breast cancer exposed to endocrine therapy and APOE4 carriers in particular exhibited lower learning and memory scores than other groups (P < .05). Our results suggest endocrine therapy may have long-term effects on cognitive function in women with breast cancer, particularly APOE4 carriers. Further characterization of genetic risk for long-term cognitive decline will be useful to inform survivorship care of older women.
Indexed as
Antineoplastic Agents, HormonalApolipoprotein E4Breast NeoplasmsCognitionCognition DisordersAgedAndrostadienesFemaleFollow-Up StudiesHeterozygoteHumansMemoryMiddle AgedNitrilesTamoxifenTime FactorsAndrostadienesAntineoplastic Agents, HormonalApolipoprotein E4NitrilesTamoxifen
Identifiers
PMID41844559
PMCPMC13127418
What Socratic holds
Textmetadata
LicenceCC BY-NC
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