Evidence map›Paper›PMID 41844639›Full record

ArticleNature communications2026

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Jenna L Wingfield, Lukas Niese, Yosef Avchalumov, Xiaodan Liu, Rahul Grover, Yoshihisa Nakahata, Bindu L Raveendra, Adrian E Gonzalez-Santiago, Jackson P Carter, Ryohei Yasuda and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Non-transport functions of motor proteins in corticogenesis.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jenna L WingfieldDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.ORCID http://orcid.org/0000-0002-9522-4183
Lukas NieseB CUBE-Center for Molecular Bioengineering, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0009-0009-2168-1099
Yosef AvchalumovDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Xiaodan LiuMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Rahul GroverB CUBE-Center for Molecular Bioengineering, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0002-5373-6578
Yoshihisa NakahataMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.ORCID http://orcid.org/0000-0003-3403-4527
Bindu L RaveendraDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Adrian E Gonzalez-SantiagoDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Jackson P CarterDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Ryohei YasudaMax Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Jason X-J YuanDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Stefan DiezB CUBE-Center for Molecular Bioengineering, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0002-0750-8515
Sathyanarayanan V PuthanveettilDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA. sputhanveettil@ufl.edu.ORCID http://orcid.org/0000-0002-1302-6766

Funding

Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 1F32MH131420-01A1Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 1R01MH119541-01A1Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) 5R01MH094607-05Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01MH118444
6 · The paper itself

Abstract

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disabilities (MCLID) is a rare disease caused by mutations in the mitotic motor KIF11. However, the specific neuronal functions of KIF11, its mechanisms of microtubule (MT) regulation, and the impact of MCLID mutations on KIF11 function remain underexplored. Here, using live-imaging, we find that KIF11 depletion in postmitotic neurons increases minus-end-out MT dynamics in both axons and dendrites. Introducing MCLID-associated KIF11 mutations, KIF11

Indexed as

DendritesIntellectual DisabilityKinesinsMicrotubulesMutationAnimalsAxonsHumansMiceNeuronsKIF11 protein, humanKif11 protein, mouseKinesins

Identifiers

PMID41844639
PMCPMC13149629

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.