SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway.

Gang Wang, Shuyu Ma, Linjie Qi, Jianhua Wang, Ying Zhou, LiJiao Jia, Guang Hao, Zuopeng Li

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

8 authors.

Gang Wang *Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Shuyu Ma *Department of School of Clinical Medicine, The First Clinical Medical College of Shanxi Medical University, Taiyuan, 030000, China.

Linjie QiDepartment of The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Jianhua WangDepartment of Zhangjiakou Hospital of Traditional Chinese Medicine, Zhangjiakou, 075000, China.

Ying ZhouDepartment of ICU, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

LiJiao JiaDepartment of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Guang HaoDepartment of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Zuopeng LiDepartment of Neurology, The First Clinical Medical College of Shanxi Medical University, No. 85, Jiefang South Road, Yingze District, Taiyuan, 030000, Shanxi, China. 13485380083@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To access the effect of SIRT1 in cerebral infarction and to explore its mechanism of ferroptosis. Bioinformatic Analysis was used to discover the associations between Ferroptosis-Related Genes and Cerebral Infarction.Rat cerebral infarction model was induced by transient middle cerebral artery occlusion followed by reperfusion.In vitro experiments, astrocytes were subjected to different stimuli.HE staining was used to observe the area of cerebral infarction in rat models.The expression of autophagy proteins and ferroptosis-related proteins in vivo and vitro experiments was accessed by using Western blot analysis and immunofluorescence, and apoptosis was detected by flow apoptosis assay. Detection of MDA, Fe

Indexed as

Cerebral InfarctionFerroptosisForkhead Box Protein O1Sirtuin 1AnimalsApoptosisAstrocytesMaleRatsRats, Sprague-DawleyReceptor, Notch1Signal TransductionYAP-Signaling ProteinsForkhead Box Protein O1Foxo1 protein, ratNotch1 protein, ratReceptor, Notch1Sirt1 protein, ratSirtuin 1Yap1 protein, ratYAP-Signaling ProteinsCerebral infarctionE2F1/NOTCH-1/YAPFerroptosisFOXO1/autophagy/NCOA4SIRT1

Identifiers

PMID41844756

DOI10.1038/s41598-026-44355-1

PMCPMC13133163

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.