ArticleBMC nephrology2026
Renal consequences of prematurity and utility of serum uromodulin as a marker of kidney growth- a cross sectional single centre study.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrematurity has been postulated to have adverse effects on nephron endowment. The objectives of the study was to study the kidney consequences of prematurity in childhood. We also studied the serum uromodulin levels in children with premature birth and its correlation with kidney growth. MATERIALS AND
methodsThis cross-sectional study was conducted from January to December 2019 included children aged 3 to 6 years with history of premature birth from 2014 to 2016. Impact of prematurity on clinical parameters such as growth, blood pressure, kidney volume were studied. In addition serum uromodulin estimated by enzyme linked immunoassay kit was used to correlate with mean kidney volume (MKV), hypertension and chronic kidney disease (CKD).
resultsIn this single centre cross-sectional study outcomes of 37 children with history of prematurity were analysed. Median (IQR) age of the cohort was 5.8 years(4 to 6.6). The mean (SD) gestational age of the cohort was 30 (2) weeks with mean (SD) birth weight of 1359.7 g(333.8). Premature rupture of membranes(12/3,32.4%) and pregnancy induced hypertension(9/37,24.3%) were common antenatal risk factors.On follow up 21.6%(8/37) had elevated BP and hypertension, 2.7%(1/37) had CKD. Serum uromodulin levels upto 100ng/ml had significant association with lower MKV(p value 0.002), with cut off value of < 52ng/ml was significantly associated with lower MKV(< 32 ml)with AUC by ROC of 0.715, sensitivity of 87% and specificity of 55%(p value 0.02).
conclusionPrematurity is noted to have impact on renal health with risk of hypertension, lower kidney volume and CKD in childhood. In addition serum uromodulin level is significantly associated with lower mean kidney volume in children with premature birth.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.