Evidence map›Paper›PMID 41845254›Full record

ArticleBMC cardiovascular disorders2026

Effects of antihypertensive therapy on matrix metalloproteinase-9 levels in controlled hypertensive patients.

José Fernando Vilela-Martin, Tatiana Palotta Minari, Marco Antônio Vieira da Silva, Valquíria da Silva Lopes, Kléber Aparecido de Oliveira, Marco Aurélio de Almeida, Riccardo Lacchini, José Eduardo Tanus-Santos, Heitor Moreno, Juan Carlos Yugar-Toledo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

José Fernando Vilela-MartinDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Tatiana Palotta MinariDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil. tatiana.minari@unifesp.br.ORCID 0000-0003-2008-9287
Marco Antônio Vieira da SilvaDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Valquíria da Silva LopesDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Kléber Aparecido de OliveiraDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Marco Aurélio de AlmeidaDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Riccardo LacchiniDepartment of Psychiatric Nursing and Human Sciences, Ribeirão Preto College of Nursing, University of São Paulo (USP), São Paulo, Brazil.
José Eduardo Tanus-SantosDepartment of Pharmacology, Medical School at Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Heitor MorenoDepartment of Internal Medicine, Medical School at Campinas, University of Campinas, São Paulo, Brazil.
Juan Carlos Yugar-ToledoDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.
Luciana Neves Cosenso-MartinDepartment of Internal Medicine, Faculdade de Medicina de São José do Rio Preto (FAMERP), Ave Brig Faria Lima 5416, São José do Rio Preto , São Paulo, 15090-000, Brazil.

Funding

Sao Paulo Research Foundation 2016/08203-6The National Council for Scientific and Technological Development 001
6 · The paper itself

Abstract

Ambulatory blood pressure monitoring (ABPM), alongside peripheral blood pressure (BP) measurements, provides valuable insights into central hemodynamics, including pulse wave velocity (PWV), augmentation index (AI75%), and central pressure-factors closely linked to arterial stiffness. The progression of arterial stiffness is associated with matrix metalloproteinase-9 (MMP-9), an extracellular matrix enzyme. This study aims to assess the correlation between variables obtained through ABPM and MMP-9 levels across different BP categories. A total of 101 individuals were enrolled, divided into three groups: 21 normotensive (NT), 36 prehypertensive (PH), and 44 controlled hypertensive (CHT) participants. Peripheral and central BP parameters were evaluated using the Mobil-O-Graph

Indexed as

Antihypertensive AgentsBlood PressureHypertensionMatrix Metalloproteinase 9PrehypertensionAdultAgedBiomarkersBlood Pressure Monitoring, AmbulatoryFemaleHumansMaleMiddle AgedPulse Wave AnalysisTime FactorsTreatment OutcomeAntihypertensive AgentsBiomarkersMatrix Metalloproteinase 9MMP9 protein, humanAmbulatory blood pressure monitoringArterial stiffnessHypertensionMatrix metalloproteinasePrehypertension

Identifiers

PMID41845254
PMCPMC13107584

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.