ArticleBMC pregnancy and childbirth2026
Euploid sporadic miscarriage in advanced-age women is associated with reduced live birth rates in subsequent pregnancies.
Article in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEuploid miscarriage may indicate underlying non-genetic factors in the couples. This study aimed to investigate the subsequent live birth rates in women with a prior euploid or aneuploid sporadic miscarriage (SM) in assisted reproductive technology (ART).
methodsThis retrospective study included 1,186 eligible women with a prior cytogenetically confirmed SM who underwent subsequent blastocyst transfer cycles. The pregnancy outcomes were compared by maternal age and the ploidy of the previous miscarriage.
resultsIn women aged < 35 years, the subsequent live birth rate (LBR) was comparable between euploid and aneuploid SM groups (55.2% vs. 60.2%; P = 0.194). However, among women aged 35–37 years, the LBR was significantly lower in those with a previous euploid SM than in those with a history of aneuploid SM (38.2% vs. 52.6%; P = 0.038). Among women ≥ 38 years, the euploid SM group also demonstrated a lower LBR (26.7% vs. 39.8%; P = 0.072). After adjusting for confounders, prior aneuploid SM was associated with significantly higher odds of live birth in the 35–37 years group (aOR 1.861; 95% CI 1.030–3.361; P = 0.040), and a similar trend was observed in the ≥ 38 years group (aOR 2.251; 95% CI 0.977–5.190; P = 0.057).
conclusionA single euploid SM might be associated with reduced live birth rate in their subsequent pregnancies for women aged ≥ 35 years. However, the pregnancy outcomes were comparable in women aged <35 years, regardless of the karyotype of products of conception.
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