Evidence map›Paper›PMID 41845345›Full record

ArticleJournal of nanobiotechnology2026

A core-shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing.

Yuhang Zhan, Zhihan Zhang, Zhiyue Zhang, Mengru Lin, Hui Liu, Dilihumaer Abulimiti, Shami Aihemaiti, Yun Kan, Jinhai Tan, Xi Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuhang Zhan *Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Zhihan Zhang *Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Zhiyue Zhang *School of Basic Medicine, Peking Union Medical College, Beijing, China.
Mengru LinCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Hui LiuDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Dilihumaer AbulimitiDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Shami AihemaitiDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Yun KanDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.
Jinhai TanDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China. zn000392@whu.edu.cn.
Xi ChenDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China. jjchen0908@hotmail.com.
Shengxiang TaoDepartment of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China. taoshengxiang@whu.edu.cn.

Funding

National Natural Science Foundation of China 82102626Zhongnan Hospital of Wuhan University KYXM2022015Zhongnan Hospital of Wuhan University ZNJC202310
6 · The paper itself

Abstract

Chronic non-healing of diabetic wound (DW) remains a critical clinical challenge worldwide. Sustained oxidative stress and prolonged inflammatory responses disrupt the wound microenvironment, while bacterial colonization and biofilm formation on the wound bed compromise drug penetration, consequently leading to suboptimal outcomes with conventional approaches. Here, we developed a core-shell structured microneedle (MN) patch system, designated as MN@Ple/Exo

Indexed as

Diabetes Mellitus, ExperimentalMicroneedle Drug DeliveryWound HealingAnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsBiocompatible MaterialsCell LineCoculture TechniquesEscherichia coliFerroptosisGene Expression ProfilingHumansMaleMiceAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsBiocompatible MaterialsAntibacterial activityCore-shell microneedleDiabetic wound healingExosomesFerroptosis

Identifiers

PMID41845345
PMCPMC13107679

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.