ReviewJournal of ovarian research2026
Critical roles of Hedgehog signaling pathway in regulating the multidrug resistance of ovarian cancer.
Review in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Ovarian cancer (OC) is a life-threatening disease with high morbidity and mortality rates among women. Treatment inevitably requires the use of multiple drugs, including platinum-based agents, taxanes, and targeted therapies, across all stages and subtypes. However, multidrug resistance frequently develops, resulting in poor prognosis and recurrence. Exploring the mechanisms of this resistance and identifying methods to restore drug sensitivity have become urgent. Current research indicates that the Hedgehog (Hh) signaling pathway is associated with the development of tumor stemness and is closely linked to the emergence of multidrug resistance in OC. However, the specific mechanisms by which Hh signaling contributes to multidrug resistance and how this pathway can be effectively targeted to restore drug sensitivity remain insufficiently understood. This article systematically summarizes the major forms of drug resistance in OC and elucidates the roles and mechanisms of the Hh pathway in multidrug resistance. These include cell stemness, spheroid formation, tumor microenvironment changes, drug efflux and metabolism, DNA damage repair, and epithelial-mesenchymal transition. Additionally, the changes in multidrug resistance-related signaling pathways caused by Hh were reviewed. Finally, we discussed strategies to sensitize OC by targeting the Hh pathway in combination with chemotherapy or targeted drugs. This approach represents a promising strategy to overcome multidrug resistance in OC.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.