Evidence map›Paper›PMID 41845517›Full record

ReviewAnimal microbiome2026

Harnessing the early-life gut microbiome for sustainable ruminant production.

Limei Lin, Milka Popova, Ilma Tapio, Le Luo Guan, Jana Seifert

Abstract readReview
In one paragraph

Review in Animal microbiome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Limei LinFaculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Milka PopovaUniversité Clermont Auvergne, INRAE, VetAgro Sup, UMR Herbivores, Saint-Genès-Champanelle, France.
Ilma TapioProduction Systems, Genomics and Breeding, Natural Resources Institute Finland (Luke), Jokioinen, 31600, Finland.
Le Luo GuanFaculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Jana SeifertDepartment of Functional Microbiology of Livestock, University of Hohenheim, 70593, Stuttgart, Germany. jseifert@uni-hohenheim.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome is a dynamic and complex ecosystem that plays an important role in determining ruminant health, productivity, and environmental footprint. Its plasticity during early life presents a critical window for potential programming of long-term physiological and functional capacities, with early interventions demonstrating greater effectiveness compared to those applied in the stable adult microbiome. This review synthesizes current evidence on the assembly of the early-life gut microbiome, elucidates the mechanisms and effectiveness of various interventions (including nutritional, microbial, and genetic approaches), and evaluates their impacts on feed efficiency, animal health, and methane emissions. While various intervention strategies offer promise for advancing ruminant production, challenges remain due to the inconsistency and variability in the persistence and long-term efficacy of these protocols. We highlight the urgent need for integrated and standardized intervention strategies, alongside longitudinal, multi-omics research, and the application of artificial intelligence, to fully unlock the transformative potential of early-life microbiome modulation. Such efforts are essential to aligning ruminant production systems with global food security and climate sustainability goals.

Indexed as

Animal nutritionEarly life microbiomeHusbandryYoung ruminants

Identifiers

PMID41845517
PMCPMC13063736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.