Evidence map›Paper›PMID 41845579›Full record

ArticleMagnetic resonance in medicine2026

Simultaneous Assessment of Skeletal Muscle Energetics and Blood Flow During Dynamic Exercise by Interleaved

T Jake Samuel, Sandeep K Ganji, Joseph R Goldenberg, Sabra C Lewsey, Allison G Hays, Robert G Weiss, Michael Schär

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T Jake SamuelDivision of Magnetic Resonance Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7638-1864
Sandeep K GanjiNorth America Clinical Science, MR R&D, Philips, Cambridge, Massachusetts, USA.ORCID 0000-0002-0247-7596
Joseph R GoldenbergDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9451-8235
Sabra C LewseyDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-8406-8472
Allison G HaysDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2138-1589
Robert G WeissDivision of Magnetic Resonance Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1844-8677
Michael SchärDivision of Magnetic Resonance Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7044-9941

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Karen J. Bandeen-Roche · 2003 to 2026
$33.2M
PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
CONTRIBUTION OF ENERGY DEPLETION TO HUMAN HEART FAILURER01HL061912 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 1999 to 2020
$8.0M
Mitochondrial energetics, exercise intolerance and fatigability in older people with HIVR01AG063661 · NIA · JOHNS HOPKINS UNIVERSITY · PI WEISS, ROBERT G · 2019 to 2024
$3.3M
Contribution of Biological, Physiological and Gait Mechanisms to High Metabolic Cost of Walking in Older AdultsR01AG095963 · NIA · JOHNS HOPKINS UNIVERSITY · PI JENNIFER ANN SCHRACK, ROBERT G WEISS · 2025 to 2026
$1.3M
Sex-specific factors, inflammation and vascular health across the lifespan in women living with HIVR35HL172680 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Allison G Hays · 2024 to 2026
$1.0M
Muscle metabolism, metabolic modulators and disabling exercise intolerance in the daily life of patients with heart failure and preserved ejection fractionK99HL171873 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SAMUEL, THOMAS JAKE · 2024 to 2025
$227k
Clarence Doodeman Endowment in Cardiology at Johns Hopkins University T32HL007227Johns Hopkins Older Americans Independence Center Junior Faculty Investigator Award from the Johns Hopkins University Claude D. Pepper Older Americans Independence Center P30AG021334NHLBI NIH HHS K99 HL171873NHLBI NIH HHS R01 HL061912NHLBI NIH HHS R35 HL172680NHLBI NIH HHS T32 HL007227NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG063661NIA NIH HHS R01 AG095963NIH HHS AG063661NIH HHS AG063661-03S1NIH HHS AG095963NIH HHS HL171873NIH HHS HL61912
6 · The paper itself

Abstract

purposeTo simultaneously measure skeletal muscle energetics and blood flow (BF) before, during, and after dynamic plantar flexion exercise (PFE).

methodsNon-localized pulse-acquire phosphorus-31 magnetic resonance spectroscopy (

resultsResting phosphocreatine (PCr) and inorganic phosphate concentrations were similar between both techniques (both p > 0.05). During PFE, PCr declined to 46% ± 10% of rest. PCr recovery time was 43 ± 15 s. Resting BF was 132 ± 43 mL/min and increased up to four-fold during PFE depending on exercise stage and pedal position. Notably, there was excellent agreement between the interleaved and conventional BF measures (r

conclusionThe feasibility of simultaneous assessment of skeletal muscle energetics and BF during dynamic exercise by interleaved

Indexed as

ExerciseMagnetic Resonance ImagingMuscle, SkeletalAdultBlood Flow VelocityEnergy MetabolismFemaleHumansMagnetic Resonance SpectroscopyMalePhosphocreatinePhosphorus IsotopesPost-Exercise RecoveryRegional Blood FlowReproducibility of ResultsYoung AdultPhosphocreatinePhosphorus Isotopes

Identifiers

PMID41845579
PMCPMC13077704

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.