ArticleJournal of clinical laboratory analysis2026
Indirubin and Retinoic Acid Show Binding Affinity to Monocyte Biomarker CSF3R in Parkinson's Disease.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study integrated multi-omics data analysis to elucidate key molecular alterations associated with monocytes in Parkinson's disease (PD) so as to identify novel biomarkers.
methodsSingle-cell and chip datasets were derived from Gene Expression Omnibus (GEO) database. Single cell atlas of PD peripheral blood was delineated by Seurat package. CellChat was utilized for cell-cell communication analysis. Critical modules and Hub genes were screened by hdWGCNA. Differentially expressed genes (DEGs) between PD and control samples were recognized via Limma package, which were intersected with Hub genes to identify monocyte-related biomarkers. Functional enrichment analysis was conducted using GSEA_4.2.2 software. Targeted drugs of biomarkers were predicted to establish molecular docking models by AutoDocktools.
resultsThe single-cell data revealed that 10 cell subpopulations were identified in PD peripheral blood, of which CD8
conclusionThis study is the first to combine single-cell sequencing with hdWGCNA to identify two biomarkers closely associated with monocytes in peripheral blood from PD patients, while also predicting potential target drugs. These findings provide new evidence for elucidating the immunopathological mechanisms of PD and offer potential directions for future development of peripheral immune-based diagnostic strategies and targeted therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.