ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
Comparative Association of Basal and Basal-Prandial Insulin Regimens on Remnant Cholesterol and Lipid Profiles in Patients with Type 2 Diabetes Mellitus.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association Between Insulin Regimen and Cardiovascular Risk in Indonesian Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.Therapeutics and clinical risk management · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: The relationship between remnant cholesterol (RC) and insulin therapy is a critical issue in public health. Each insulin regimen used in T2DM patients can have different effects on lipid metabolism. However, clinical evidence comparing the effects of basal insulin and combined basal-prandial insulin on RC levels is limited. Purpose: To investigate and compare the association between basal and basal-prandial insulin regimens on RC and lipid profiles of patients with T2DM using a cross-sectional measurement. Methods: The study involved 118 eligible T2DM patients receiving either basal or combined basal-prandial insulin at Dr. Wahidin Sudirohusodo General Hospital, Makassar, Indonesia. Bivariate analysis was performed using the Chi-square test. Multiple logistic regression was used to identify independent factors associated with RC levels. Results: The study reveals that the proportion of patients with normal RC level was significantly greater in the basal-prandial group than in the basal insulin group (49.2% and 30.5%, respectively, Conclusion: Compared to basal insulin therapy alone, the combination of basal-prandial insulin regimen was more beneficial in maintaining normal RC levels, although its effects were partially mediated by HDL-C, DM duration, and BMI. Therefore, clinical decisions aimed at improving RC levels in T2DM should consider overall metabolic factors, including HDL-C status, DM duration, and adiposity, rather than on insulin regimen type alone.
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