Evidence map›Paper›PMID 41847046›Full record

ArticlebioRxiv : the preprint server for biology2026

Traceless protein semi-synthesis in cells using the promiscuous ultra-fast split intein NrdJ-1.

Xuanjia Ye, Joshua Sokol, Christian Kofoed, Anushka Dheer, Juner Zhang, Tom W Muir

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xuanjia YeDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6277-6045
Joshua SokolDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Christian KofoedDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8258-5887
Anushka DheerDepartment of Chemistry, Princeton University, Princeton, NJ, USA.
Juner ZhangDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-8181-1187
Tom W MuirDepartment of Chemistry, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-9635-0344

Funding

Structure, Function and Applications of InteinsR01GM086868 · NIGMS · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2008 to 2025
$4.4M
NIGMS NIH HHS R01 GM086868
6 · The paper itself

Abstract

Chemistry-driven approaches that allow proteins to be manipulated in ways not permitted by standard genetics are indispensable in the basic and applied biomedical sciences. Of the various platform technologies in common use, those that exploit intein-mediated protein splicing have proven especially powerful owing to compatibility with both

Identifiers

PMID41847046
PMCPMC12991169

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.