ArticlePeerJ2026
Proteome analysis of lysine crotonylation modification in patients with psoriasis.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Lysine crotonylation, particularly on histones, has recently emerged as a prominent focus in post-translational modification research. While it has been extensively studied in oncology, its role in skin diseases remains largely unexplored. To address this gap, we enrolled 45 psoriasis patients from outpatient clinics and compared crotonylation profiles between lesional and non-lesional skin tissues. Although many modifications were conserved across both tissue types, several differences were observed. We identified 100 upregulated and 76 downregulated lysine crotonylation sites in psoriatic lesions. The most significantly upregulated site was detected in COL6A3 (ratio = 3.07,
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