ArticleFrontiers in cardiovascular medicine2025
The role of systemic inflammatory response index in predicting myocardial infarction in patients with unstable angina.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction.Cardiovascular toxicology · 2026Review
- Association between systemic inflammation response index and risk of major adverse cardiovascular events in adults with and without metabolic syndrome: a prospective cohort study in Shanghai, Pudong.Frontiers in endocrinology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Unstable angina (UA) is a high-risk presentation of acute coronary syndrome (ACS) that can rapidly progress to myocardial infarction (MI) if not identified and managed promptly. Inflammation plays a key role in plaque instability and thrombotic events, making inflammatory biomarkers useful tools for early risk assessment. The Systemic Inflammatory Response Index (SIRI), derived from peripheral blood cell counts, has emerged as a novel marker of systemic inflammation, but its prognostic utility in UA remains underexplored. Objective: The purpose of this study was to investigate the role of the Systemic Inflammatory Response Index (SIRI) in predicting myocardial infarction and major adverse cardiovascular events (MACE) in patients presenting with unstable angina. Methods: This retrospective observational study included 129 adult patients diagnosed with unstable angina and admitted to a tertiary care center. SIRI was calculated as (neutrophil count × monocyte count)/lymphocyte count using laboratory values obtained at admission. Patients were stratified into low and high SIRI groups based on a cutoff derived from ROC analysis. Clinical, laboratory, and angiographic data were collected, and outcomes including MI and MACE (composite of MI, cardiovascular death, stroke, and urgent revascularization) were assessed. ROC curves, logistic regression, and Kaplan-Meier analysis were used for statistical evaluation. Results: Patients with high SIRI levels had significantly higher rates of myocardial infarction (38% vs. 10%, Conclusion: SIRI is a simple, accessible, and powerful inflammatory marker that independently predicts myocardial infarction and MACE in patients with unstable angina. Its integration into early risk assessment may enhance clinical decision-making and improve patient outcomes.
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