Background: Age-related memory decline has emerged as a critical global public health challenge, yet few ethnopharmacological interventions have demonstrated robust clinical efficacy in improving memory and cognitive function. Objectives: This randomized, double-blind, placebo-controlled trial aimed to elucidate the neurocognitive-enhancing mechanisms of a botanical product containing Methods: 117 healthy participants (aged 30-65 years) were randomized to receive either CG tablets or placebo for 30 days. Clinical memory assessments and MRI scans were conducted at baseline and post-intervention. Gray matter volume (GMV), functional MRI (fMRI), and functional connectivity (FC) were analyzed using SPM12. Results: CG tablets significantly improved scores in across multiple dimensions, including directional memory, associative learning, graphic free recall, portrait memory, total memory, and Memory Quotient (all Conclusion: These findings indicated that CG supplementation enhances memory function in healthy adults. These cognitive gains are linked to specific structural and functional neural changes, particularly in motor-related areas and the cerebellum, reflecting improved neural processing. While these findings highlight CG's short-term benefits, further research is warranted to explore its long-term efficacy and broader clinical utility.This study was registered at the Chinese Clinical Trials Registry (https://www.chictr.org.cn/): ChiCTR2400084102. Clinical Trial Registration: https://www.chictr.org.cn/hvshowproject.html?id=251905&v=1.0, identifier ChiCTR2400084102.