ArticleInternational journal of general medicine2026
The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the prognostic value of the systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) in predicting healing outcomes in patients with diabetic foot ulcers (DFUs) treated with Moist Exposed Burn Ointment (MeBo). Methods: This retrospective study analyzed 273 DFU patients treated at the First Hospital of Qinhuangdao (January 2022-December 2024). Patients were categorized into complete healing (n=123) and non-healing (n=150) groups based on 12-week outcomes. Univariate and multivariate logistic regression analyses were conducted to identify predictors of healing. Receiver operating characteristic (ROC) curve analysis evaluated the discriminative abilities of SII and PNI. Results: Compared to the non-healing group, the complete healing group exhibited significantly lower SII (1444.82±560.26 vs. 2979.88±1357.18, P<0.001) and higher PNI (38.17±5.20 vs. 31.65±5.54, P<0.001). ROC analysis indicated that SII had strong predictive ability (AUC=0.920, P<0.001; optimal threshold 1901.48), with 86.0% sensitivity and 83.7% specificity. PNI showed moderate predictive capacity (AUC=0.811, P<0.001). Notably, the combined model (SII+PNI) demonstrated superior predictive performance (AUC=0.940), achieving 89.3% sensitivity and 87.0% specificity. Conclusion: SII and PNI are robust prognostic biomarkers for DFU patients treated with MeBo. Elevated SII acts as a risk factor for non-healing, while higher PNI serves as a protective factor. Integrating these indices into clinical practice may facilitate early risk assessment and guide therapeutic strategies to improve healing outcomes.
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