Evidence map›Paper›PMID 41847240›Full record

ArticleClinical optometry2026

Superficial Keratectomy with Cryopreserved Amniotic Membrane for Ocular Surface Optimization in Patients with Epithelial Basement Membrane Dystrophy.

S Wade Kimmell

Abstract read
In one paragraph

Article in Clinical optometry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

S Wade KimmellDepartment of Optometry, Eye Surgeons of Indiana, Lafayette, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Epithelial Basement Membrane Dystrophy (EBMD)-induced irregular astigmatism can lead to unreliable biometry and suboptimal refractive outcomes in cataract surgery patients. Herein, we assessed the use of superficial keratectomy followed by placement of cryopreserved amniotic membrane (cAM) to improve the ocular surface. Methods: This was a single-center, retrospective study of consecutive patients with EBMD that underwent superficial keratectomy with adjunctive treatment with cAM between November 2022 and March 2025. Time to complete epithelialization, visual acuity (LogMAR), higher order aberration Root Mean Square (HOA RMS), cylinder power, and IOL biometry were assessed up to two months post-treatment. Results: A total of 27 eyes of 21 patients with EBMD were included in the study and received cAM for a mean of 3.0 ± 0.4 days. Complete re-epithelialization was noted in an average 7.0 ± 4.7 days, with 96.3% (26/27) of eyes achieved epithelialization within 10 days. At the two month follow up, LogMAR VA slightly improved from 0.34 ± 0.21 to 0.31 ± 0.23 (p=0.42). HOA RMS significantly improved from 0.68 ± 0.53 μm to 0.42 ± 0.23 μm (p=0.006), and cylinder power significantly changed from 1.38 ± 0.75 D to 1.09 ± 0.71 D (p=0.022). Conclusion: Superficial keratectomy with cAM led to complete re-epithelialization in the majority (96.3%) of cases within 10 days, which was associated with a significant change in HOA RMS, cylinder power and IOL SE. This treatment may be considered in patients prior to cataract surgery to return the cornea to healthy state and change the biometry input for IOL selection.

Indexed as

amniotic membraneanterior basement membrane dystrophycataract surgerycryopreservationdebridementepithelial basement membrane dystrophykeratectomyocular surface

Identifiers

PMID41847240
PMCPMC12991371

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.