ArticleRisk management and healthcare policy2026
Association of Cumulative Average Uric Acid to HDL Cholesterol Ratio with the Risk of Rapidly Declining Renal Function: A Retrospective Community-Based Cohort Study in Shanghai Undertaken on Elderly Subjects with Hypertension and Type 2 Diabetes Mellitus Patients.
Article in Risk management and healthcare policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Background: In patients ≥60 years with hypertension and type 2 diabetes mellitus, triglyceride-glucose index (TyG), TyG-BMI, uric acid to high-density lipoprotein cholesterol ratio (UHR), atherogenic index of plasma (AIP), single point insulin sensitivity estimator (SPISE Index) and their cumulative averages are linked to rapid kidney function decline (RD). This study aimed to identify the parameter most strongly independently associated with RD. Methods: A retrospective cohort study used electronic records from Shanghai Chuansha Huaxia Community Health Service Center. Consecutive patients ≥60 years with both diseases (January 2020-December 2023) were enrolled and divided into RD (n=151) and Non-RD (n=499) groups based on 4-year eGFR trajectory. Results: RD group had higher age, cum TyG, UHR, cum UHR, and cum AIP (all Conclusion: Elevated cum UHR is significantly associated with RD in these patients and may serve as a valuable biomarker for high-risk individual identification.
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