ArticleInfection and drug resistance2026
Combating Antimicrobial Resistance: A Pharmacist-Led PDCA Stewardship Program in a Tertiary Hospital.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Combating Antimicrobial Resistance: A Pharmacist-Led PDCA Stewardship Program in a Tertiary Hospital [Letter].Infection and drug resistance · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antimicrobial resistance (AMR) is a critical global health threat driven by inappropriate antimicrobial use. Reducing antimicrobial consumption and optimizing prescribing are fundamental goals of Antimicrobial Stewardship Programs (ASPs). This study aimed to implement and evaluate a pharmacist-led, multidimensional ASP based on the Plan-Do-Check-Act (PDCA) cycle to reduce Antibacterial Use Density (AUD) and improve prescribing quality. Methods: A quasi-experimental study was conducted from October 2023 to September 2024 in a tertiary hospital. Led by a multidisciplinary ASP team and guided by the PDCA cycle, the intervention comprised: 1) an innovative "1+X" ward-based clinical pharmacist model to standardize surgical antimicrobial prophylaxis (SAP); 2) promoting precision diagnostics via Therapeutic Drug Monitoring (TDM) and droplet digital PCR (ddPCR); 3) establishing regular multidisciplinary case discussions; and 4) integrating informatics-driven alerts into the prescribing system. Data on AUD, SAP quality, diagnostic utilization, and cost were extracted from the hospital information system and analyzed. Results: Hospital-wide AUD significantly decreased by 25.06%, from 49.68 to 37.23 DDDs/100 patient-days ( Conclusion: A pharmacist-led, PDCA-based ASP integrating differentiated strategies and precision diagnostics effectively reduced antimicrobial consumption, optimized prescribing structure, improved SAP quality, and generated economic benefits. This model provides a replicable framework for sustainable antimicrobial stewardship in hospitals.
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