ArticleFrontiers in endocrinology2026
Uric acid and hyperuricemia in relation to non-alcoholic fatty liver disease among individuals with type 2 diabetes: insights from a cross-sectional analysis.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Association between the Zhejiang University index and hyperuricemia among adults with type 2 diabetes in China.Frontiers in endocrinology · 2026Article
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4 authors.
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Abstract
Aims: Considering the growing evidence linking metabolic abnormalities with liver diseases, in adults with type 2 diabetes mellitus (T2DM), this research examined the relationship between serum uric acid (UA), hyperuricemia, and non-alcoholic fatty liver disease (NAFLD) in T2DM patients. Methods: Between January 2024 and January 2025, 952 individuals with T2DM were enrolled in a single-center cross-sectional investigation conducted at the Zhengzhou People's Hospital. Associations of UA and hyperuricemia with NAFLD were evaluated using multivariate logistic regression, accompanied by subgroup and sensitivity analyses. Restricted cubic spline (RCS) and generalized additive models (GAM) anlyses were applied to examine the non-linear dose-response association between UA and NAFLD. Results: Using the fully adjusted multivariate logistic regression model, hyperuricemia was found to be independently linked to a higher risk of NAFLD (OR 1.660, 95% CI: 1.094-2.521, Conclusion: Serum UA levels and hyperuricemia are independently linked to a greater likelihood of NAFLD among individuals with T2DM, underscoring the importance of UA surveillance in this group to facilitate prompt detection and precise intervention for NAFLD.
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