Evidence map›Paper›PMID 41847485›Full record

ArticleThe Canadian veterinary journal = La revue veterinaire canadienne2026

First report of malignant hyperthermia syndrome in an American Guinea hog.

Katherine Deal, Cassandra A Klostermann, Arantxa Lasa, Elizabeth K Pisack, Wesley Sheley, Chiara E Hampton

Abstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katherine DealCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).
Cassandra A KlostermannCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).
Arantxa LasaCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).
Elizabeth K PisackCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).
Wesley SheleyCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).
Chiara E HamptonCollege of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Deal); Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Klostermann, Lasa, Hampton); BluePearl Pet Hospital, Cary, North Carolina, USA (Pisack); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Sheley).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 3-year-old intact female American Guinea hog that was presented for an elective ovariohysterectomy appeared systemically healthy, with no overt medical conditions. Premedication with clonazepam, tiletamine-zolazepam, and xylazine; anesthetic induction with propofol and maintenance with isoflurane with oxygen on spontaneous ventilation; a ketamine infusion; and morphine for analgesia were provided. Approximately 95 min after isoflurane was initiated, the pig acutely became hyperthermic and severely hypercapnic, with hyperkalemia, hyperlactatemia, and severe metabolic and respiratory acidosis. With high suspicion of malignant hyperthermia syndrome (MHS), isoflurane was discontinued, and active cooling, ventilatory support, dantrolene, aggressive fluid therapy, lidocaine, insulin, and dextrose were administered. The pig developed ventricular tachycardia with subsequent cardiopulmonary arrest. Cardiopulmonary resuscitation was attempted without success. Necropsy findings were suggestive of MHS and genetic testing confirmed a dimutant

Indexed as

Malignant HyperthermiaSwine DiseasesAnesthetics, InhalationAnimalsDantroleneFemaleGuinea PigsIsofluraneRyanodine Receptor Calcium Release ChannelAnesthetics, InhalationDantroleneIsofluraneRyanodine Receptor Calcium Release Channel

Identifiers

PMID41847485
PMCPMC12990007

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.