Prognostic role of pretreatment hematologic values and albumin-globulin ratio in canine appendicular osteosarcoma.

Olivia R Geels, Michael O Childress, Stephanie E S Lindley, Noelle S Bergman, Ashley A Smith

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Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Olivia R GeelsDepartment of Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA (Geels, Childress); Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Lindley, Bergman, Smith).

Michael O ChildressDepartment of Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA (Geels, Childress); Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Lindley, Bergman, Smith).

Stephanie E S LindleyDepartment of Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA (Geels, Childress); Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Lindley, Bergman, Smith).

Noelle S BergmanDepartment of Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA (Geels, Childress); Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Lindley, Bergman, Smith).

Ashley A SmithDepartment of Clinical Sciences, Purdue University College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA (Geels, Childress); Department of Clinical Sciences, Auburn University College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA (Lindley, Bergman, Smith).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Pretreatment inflammatory indices are established negative prognostic factors for survival in human osteosarcoma (OSA). However, studies investigating these values in canine malignancies, specifically canine appendicular OSA, are limited. The prognostic significance of pretreatment inflammatory indices in canine appendicular OSA was investigated in this retrospective study. Animals and procedure: Medical records for dogs with appendicular OSA treated with amputation and adjuvant carboplatin were retrospectively reviewed. The following pretreatment values were evaluated for prognostic significance for progression-free survival (PFS) and disease-specific survival (DSS): serum alkaline phosphatase, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and albumin-to-globulin ratio. Effects of proximal humeral location, presence of metastasis at diagnosis, and use of rescue chemotherapy on prognosis were also analyzed. Results: Elevated albumin-to-globulin ratio was prognostic for PFS and DSS on univariate analysis but did not retain significance on multivariate analysis. On multivariate analysis, metastasis at diagnosis, elevated serum alkaline phosphatase, and administration of rescue chemotherapy were significantly associated with shorter PFS; whereas metastasis at diagnosis was significantly associated with DSS. Conclusion and clinical relevance: Despite pretreatment inflammatory indices being independently associated with prognosis in human OSA, these values were not associated with either PFS or DSS in this study. Prospective investigation with a larger, standardized cohort is needed to further evaluate the prognostic role of pretreatment inflammatory indices in canine OSA.

Indexed as

Bone NeoplasmsDog DiseasesGlobulinsOsteosarcomaSerum AlbuminSerum GlobulinsAnimalsAntineoplastic AgentsCarboplatinDogsFemaleMalePrognosisRetrospective StudiesAntineoplastic AgentsCarboplatinGlobulinsSerum AlbuminSerum Globulins

Identifiers

PMID41847494

PMCPMC12990003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.