Evidence map›Paper›PMID 41847595›Full record

Trial reportTransplant international : official journal of the European Society for Organ Transplantation2026

Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Transplantation - A Prospective Pilot Study.

Simon Mathis, Gabriel Putzer, Lukas Gasteiger, Nikolai Staier, Lisa Schlosser, Pia Tscholl, Robert Breitkopf, Benno Cardini, Alexander Kofler, Rupert Oberhuber and 3 more

Erratum issuedAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Simon MathisDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Gabriel PutzerDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Lukas GasteigerDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Nikolai StaierDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Lisa SchlosserData Lab Hell GmbH, Zirl, Austria.
Pia TschollData Lab Hell GmbH, Zirl, Austria.
Robert BreitkopfDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Benno CardiniDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Alexander KoflerDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Rupert OberhuberDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Thomas ReschDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Stefan SchneebergerDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Judith MartiniDepartment of Anaesthesiology and Critical Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) plays a pivotal role in liver transplantation by inducing oxidative stress and inflammation, thereby contributing to impaired graft function and postoperative complications. A key element of IRI is degradation of the endothelial glycocalyx, resulting in microcirculatory dysfunction. This study investigated the impact of normothermic machine perfusion (NMP) on glycocalyx integrity and its association with early postoperative outcomes. Thirty grafts undergoing NMP prior to transplantation were analyzed. Syndecan-1 and heparan sulfate were quantified in perfusate and recipient serum. Donor-related factors influencing glycocalyx injury during NMP were assessed, and correlations with outcomes established. Syndecan-1 levels increased during NMP and remained significantly elevated in grafts from circulatory-death (DCD) donors compared with brain-death (DBD) donors. Receiver operating characteristics revealed predictive potential for early allograft dysfunction (EAD) with a syndecan-1 cut-off of 4,796.13 ng/mL after 6 h of NMP. In contrast, heparan sulfate concentrations showed no relevant changes. Postoperatively, syndecan-1 levels in recipient serum were elevated immediately after transplantation but declined over subsequent days, while heparan sulfate remained stable. These findings indicate that glycocalyx injury develops during NMP, particularly in DCD livers, with elevated syndecan-1 reflecting endothelial vulnerability and a potentially modifiable aspect of graft physiology relevant to future protective strategies. Clinical Trial Registration: www.Clinicaltrials.gov, identifier NCT: 04764266.

Indexed as

GlycocalyxLiver TransplantationPerfusionAdultFemaleHeparan SulfateHumansLiverMaleMicrocirculationMiddle AgedPilot ProjectsProspective StudiesReperfusion InjurySyndecan-1Heparan SulfateSDC1 protein, humanSyndecan-1glycocalyxheparan sulfateliver transplantationnormothermic machine perfusionsyndecan-1

Identifiers

PMID41847595
PMCPMC12989448

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.