Evidence map›Paper›PMID 41847607›Full record

ArticleiScience2026

Crosstalk between circulating DPP3 and immune cells in the context of cardio-systemic stress.

Noma Assad, Hugo Nordin, Alexis Nguyen, Claire Oddos, Gwendolyn Marguerit, Lalou Delgado, Isabelle Schiltz, Adrien Picod, Maxime Zalc, Antoine Beurton and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Noma AssadParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Hugo NordinParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Alexis NguyenParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Claire OddosParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Gwendolyn MargueritParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Lalou DelgadoParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Isabelle SchiltzParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Adrien PicodParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Maxime ZalcParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Antoine BeurtonDepartment of Cardiovascular Anesthesia and Intensive Care, University Hospital Bordeaux, Pessac, France.
Marion TanguyUniversité Paris-Cité, Inserm, Centre de Recherche sur l'inflammation, UMR 1149, Paris, France.
Pierre-Emmanuel RautouUniversité Paris-Cité, Inserm, Centre de Recherche sur l'inflammation, UMR 1149, Paris, France.
Malha SadouneParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Evelyne PolidanoParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Jean-Marie LaunayParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Karine Santos4TEEN4 Pharmaceuticals Gmbh, Hennigsdorf, Germany.
Nicolas VodovarParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Alexandre OuattaraDepartment of Cardiovascular Anesthesia and Intensive Care, University Hospital Bordeaux, Pessac, France.
Damien LogeartParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Amélie CalmontParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Alexandre MebazaaParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.
Feriel AzibaniParis Cité University, INSERM UMR-S 942, Cardiovascular Markers in Stress Condition (MASCOT), Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dipeptidylpeptidase 3 (DPP3) is a ubiquitous intracellular peptidase recently identified in the circulation (cDPP3) as a biomarker and therapeutic target in circulatory failure. The source and mechanism of DPP3 release remain unclear. Based on increased DPP3 expression in the bone marrow compartment under stress conditions, we aimed to assess bone marrow's contribution to DPP3 release. WT bone marrow was transplanted into irradiated DPP3-knockout (KO) mice, generating KO

Indexed as

biochemistrycardiovascular medicineimmunology

Identifiers

PMID41847607
PMCPMC12989849

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.