Evidence map›Paper›PMID 41847646›Full record

ArticleACS medicinal chemistry letters2026

Isoindolines and Isoindoline-1,3-diones as Nonpeptide ACE Inhibitors: An

Jessica E Rodríguez, Jesús A Lagos-Cruz, Rafael Villalobos-Molina, Roberto I Cuevas-Hernández, Itzell A Gallardo-Ortíz, Erik Andrade-Jorge

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica E RodríguezÁrea de Química Computacional y Modelado Molecular, Bioquímica clínica, Carrera de Químico Farmacéutico Biólogo, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México. Av. Guelatao con Av. Exploradores, Ejército de Oriente, Iztapalapa, 09320 Ciudad de México, México.
Jesús A Lagos-CruzLaboratorio de Investigación en Biomedicina y Toxicología, Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n Casco de Santo Tomás, 11340 Mexico City, México.
Rafael Villalobos-MolinaUnidad de Investigación en Biomedicina y Carrera de Enfermería, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México. Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de México, México.
Roberto I Cuevas-HernándezLaboratorio de Investigación en Biomedicina y Toxicología, Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n Casco de Santo Tomás, 11340 Mexico City, México.
Itzell A Gallardo-OrtízUnidad de Investigación en Biomedicina y Carrera de Enfermería, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México. Av. de los Barrios 1, Los Reyes Iztacala, Tlalnepantla 54090, Estado de México, México.ORCID https://orcid.org/0000-0003-3879-0821
Erik Andrade-JorgeLaboratorio de Investigación en Biomedicina y Toxicología, Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n Casco de Santo Tomás, 11340 Mexico City, México.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension, a major cardiovascular risk factor, is often treated with peptide-derived angiotensin-converting enzyme inhibitors (ACEi), which can have several side effects. This study examined a new alternative: isoindoline and isoindoline-1,3-dione derivatives as nonpeptide ACE inhibitors. The synthesis and testing of these compounds involved both

Indexed as

ACE inhibitorEnzyme kineticsHypertensionLethal dose 50Molecular docking

Identifiers

PMID41847646
PMCPMC12989995

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.