ArticleJournal of the American Heart Association2026
Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca
Lin-Hong Wu, Ru-Yue Bai, Jia-Yi Chen, Zheng-Da Pang, Xia-Xia Hai, Meng-Zhuan Han, Yi-Yi Yang, Yan Wang, Yi Zhang, Jie Zhang and 3 more
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In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
Lin-Hong WuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.ORCID 0009-0008-3815-5338 Ru-Yue BaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Jia-Yi ChenSchool of Pharmacy Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Zheng-Da PangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Xia-Xia HaiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Meng-Zhuan HanDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Yi-Yi YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Yan WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Yi ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.ORCID 0000-0003-3795-4812 Gang SheDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.ORCID 0000-0001-9700-0880 Xiao-Jun DuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.ORCID 0000-0001-5213-3911 Xiu-Ling DengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.ORCID 0000-0003-3908-6086 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundMyocardial fibrosis is a pivotal pathological component of the failing heart where the sympatho-β-adrenergic receptor (β-AR) signaling is augmented. Intermediate-conductance Ca
methodsWe used 2 mouse models of established cardiac fibrosis induced by administration of isoproterenol (30 mg/kg per d SC) for 1 week with animals studied 4 weeks afterwards, or transgenic overexpression of β
resultsMice subjected to repeated isoproterenol injections developed myocardial inflammation and fibrosis with irreversible cardiac dysfunction. These phenotypes seen in both models were reversed by DMF treatment in vivo. Mechanistically, in both in vivo models and in cultured fibroblasts, we observed declined YAP phosphorylation and enhanced YAP nuclear localization induced by isoproterenol, changes accompanied by upregulation of K
conclusionsDMF reverses the established myocardial fibrosis following β-AR activation by inhibiting YAP nuclear localization and resultant K
Indexed as
Adaptor Proteins, Signal TransducingCardiomyopathiesCell Cycle ProteinsDimethyl FumarateFibroblastsIntermediate-Conductance Calcium-Activated Potassium ChannelsMyocardiumReceptors, Adrenergic, beta-2AnimalsCells, CulturedDisease Models, AnimalFibrosisIsoproterenolMaleMiceMice, Inbred C57BLAdaptor Proteins, Signal TransducingCell Cycle ProteinsDimethyl FumarateIntermediate-Conductance Calcium-Activated Potassium ChannelsIsoproterenolKcnn4 protein, mousePhosphoproteinsReceptors, Adrenergic, beta-2Yap1 protein, mouseYAP-Signaling Proteinsdimethyl fumarateKCa3.1 channelmyocardial fibrosisYAPβ‐adrenergic receptor
Identifiers
PMID41848035
PMCPMC13279060
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