ArticleJournal of the American Heart Association2026
Association of Rest-Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisrupted circadian rhythms are associated with cardiometabolic disease. We examined associations between rest-activity rhythms and cardiometabolic disease by race.
methodsIn cross-sectional analysis of the CARDIA (Coronary Artery Risk Development in Young Adults) sleep ancillary study (2020-2023), 861 participants wore wrist actigraphy for 7 days. Sleep Regularity Index and rest-activity rhythm measures were calculated: interdaily stability, intradaily variability, relative amplitude, and most active 10-hour and least active 5-hour period start times. Cardiometabolic disease markers included body mass index, waist circumference, blood pressure, hypertension, fasting glucose, estimated insulin resistance, and diabetes. Linear regression models with interaction terms evaluated effect modification by race.
resultsAmong 354 Black and 507 White participants, the most consistent associations were between anthropometric markers and rest-activity rhythms. Except for most active 10-hour start, remaining indices and Sleep Regularity Index were associated with body mass index with β coefficients ranging from -1.74 to 0.86, consistent with our hypothesis that weaker rest-activity rhythms relate to larger body mass index. There was some effect modification by race (
conclusionsLess robust rest-activity rhythms and irregular sleep were associated with less favorable anthropometric and glycemic markers but weakly associated with blood pressure, with few racial differences.
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Registered trials
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