ArticleApplied and environmental microbiology2026
Ultraviolet radiation reshapes the metabolome of skin commensal bacteria, influencing AhR signaling and barrier function.
Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Temperature and Ultraviolet Radiation Influence the Skin Microbiome of Humpback Whales.Molecular ecology · 2026Article
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7 authors.
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Abstract
Ultraviolet radiation (UVR) is an environmental stressor to the skin and its associated microbiota. Many commensal bacteria produce tryptophan-derived metabolites that modulate epidermal barrier function through aryl hydrocarbon receptor (AhR) signaling. However, the effects of UVR on these metabolic outputs and the subsequent effects on skin barrier function remain unclear. This study examined these interactions. Individual skin commensal bacteria were irradiated with 37.5 mJ/cm² or 150 mJ/cm² of solar-simulated radiation (SSR). Cell-free supernatants (CFSNs) were collected and analyzed for tryptophan metabolites (using LC-MS), untargeted metabolites (using GC-MS), and AhR agonist activity (via a reporter assay). The effects on barrier function were assessed by measuring transepithelial electrical resistance (TEER) of CFSN-treated keratinocyte cultures. Time-course expression of tryptophan-related genes after irradiation was measured by qPCR. Unirradiated bacterial metabolomes were species-specific. Following irradiation, the abundance of metabolites generated by the indole pathway generally increased after 37.5 mJ but decreased following 150 mJ. Untargeted analyses revealed several decreases in amino and organic acid production after high-dose SSR, while 37.5 mJ resulted in fewer changes. Low-dose SSR upregulated genes involved in tryptophan metabolism (
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