Evidence map›Paper›PMID 41848811›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing.

Xiaowen Lu, Christophe Morisseau, Khushi Jain, Zhong Chen, Amy J Estes, Darryl Zeldin, Artiom Gruzdev, Aniqa Ahmed, Haley Cook, Bruce D Hammock and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaowen LuDepartment of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0009-0001-3222-0361
Christophe MorisseauDepartment of Entomology and Nematology, Comprehensive Cancer Center, University of California, Davis, California, USA.
Khushi JainDepartment of Entomology and Nematology, Comprehensive Cancer Center, University of California, Davis, California, USA.
Zhong ChenDepartment of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Amy J EstesDepartment of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Darryl ZeldinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Artiom GruzdevDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.
Aniqa AhmedDepartment of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Haley CookDepartment of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Bruce D HammockDepartment of Entomology and Nematology, Comprehensive Cancer Center, University of California, Davis, California, USA.ORCID https://orcid.org/0000-0003-1408-8317
Mitchell A WatskyDepartment of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.

Funding

TRANSPORT, TRANSFORMATION &REMEDIATION OF VOCS IN THE VADOSE ZONE &GROUND WATERP42ES004699 · UNIVERSITY OF CALIFORNIA DAVIS · 1987 to 2005
$14.0M
UC Davis CounterACT Center of Excellence: Developing Therapeutic Strategies for Mitigating the Chronic Neurological Consequences of Acute Organophosphate IntoxicationU54NS127758 · UNIVERSITY OF CALIFORNIA AT DAVIS · 2025 to 2025
$3.1M
Bioactive lipids as effectors and indicators of the deleterious effects of environmental exposure on chronic diseasesR35ES030443 · UNIVERSITY OF CALIFORNIA AT DAVIS · 2025 to 2025
$1.0M
HHS | NIH | National Institute of Environmental Health Sciences (DEHS) Z01025034HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U54NS127758NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY021747NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

Cornea alkali injuries are difficult to treat and potentially blinding, and there are still no specific treatments. The cytochrome P450 arachidonic acid metabolism pathway generates epoxy fatty acids (EpFAs) which have analgesic, anti-inflammatory, and anti-fibrotic activities. EpFAs have anti-fibrotic effects in several tissues including kidney, heart, liver, and lungs, while the cornea has never been examined. Soluble epoxide hydrolase (sEH) metabolizes EpFAs to biologically less active diols, and its inhibitors (sEHi) can alleviate or prevent fibrosis. The current studies were designed to examine the role of sEHi in NaOH and ammonia wounded corneas and develop new in vitro and in vivo cornea ammonia wound models. Haziness was reduced or eliminated in NaOH wounded mouse corneas treated with sEHi by day 17 post-injury. Ammonia wounded corneas treated with sEHi did not vascularize and most of the haze resolved. αSMA, collagen III, and fibronectin were significantly decreased in NaOH and ammonia wounded corneas treated with sEHi. Fewer CD45

Indexed as

Burns, ChemicalCorneaCorneal InjuriesEnzyme InhibitorsEpoxide HydrolasesEye BurnsWound HealingAlkaliesAnimalsHumansMaleMiceMice, Inbred C57BLSodium HydroxideAlkaliesEnzyme InhibitorsEpoxide HydrolasesSodium Hydroxidealkali woundcorneaepoxide fatty acidsfibrosissoluble epoxide hydrolase

Identifiers

PMID41848811
PMCPMC12998594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.