Evidence map›Paper›PMID 41848879›Full record

ArticleWorld journal of urology2026

Urine culture-guided antibiotic prophylaxis reduces febrile pyelonephritis after ureteral stent removal following radical cystectomy.

Hiroyuki Kitano, Eisuke Watanabe, Kayoko Tadera, Yoshinori Nakano, Shinsaku Tasaka, Kazuma Yukihiro, Mai Okazaki, Naofumi Nomura, Tomoya Hatayama, Hiroyuki Shikuma and 15 more

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Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hiroyuki KitanoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. tanokin@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-2223-2403
Eisuke WatanabeDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kayoko TaderaSection of Clinical Laboratory, Division of Clinical Support, Hiroshima University Hospital, Hiroshima, 734-8551, Japan.
Yoshinori NakanoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Shinsaku TasakaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kazuma YukihiroDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Mai OkazakiDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Naofumi NomuraDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Tomoya HatayamaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hiroyuki ShikumaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kyosuke IwaneDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Ryo TasakaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yuki KohadaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kenshiro TakemotoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Shunsuke MiyamotoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Miki NaitoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kohei KobatakeDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yohei SekinoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Keisuke GotoDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Akihiro GorikiDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Keisuke HiedaDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Tetsutaro HayashiDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Seiya KashiyamaSection of Clinical Laboratory, Division of Clinical Support, Hiroshima University Hospital, Hiroshima, 734-8551, Japan.
Hiroki OhgeDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima, 734-8551, Japan.
Nobuyuki HinataDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate whether urine culture-guided prophylactic antibiotic selection reduces infectious complications after ureteral stent removal following radical cystectomy with intestinal urinary diversion.

methodsWe retrospectively analyzed 128 patients who underwent radical cystectomy with intestinal urinary diversion between February 2009 and July 2025. Patients were divided into a culture-guided prophylaxis group and an empirical prophylaxis group. The primary endpoint was febrile pyelonephritis after ureteral stent removal. Multivariable logistic regression analysis was performed to identify independent risk factors for post-stent removal infection.

resultsPatients in the culture-guided group more frequently received antithrombotic therapy, neoadjuvant chemotherapy, and robot-assisted surgery, and had shorter operative times and less blood loss. Febrile pyelonephritis occurred in 2 patients (3%) in the culture-guided group and 10 patients (16%) in the empirical group (P < 0.05). Enterococcus faecalis was the most commonly isolated pathogen. Multivariable analysis identified urine culture-guided prophylactic antibiotic selection as an independent protective factor against febrile pyelonephritis (odds ratio 0.139, P = 0.04), while antithrombotic therapy was an independent risk factor.

conclusionsUrine culture-guided prophylactic antibiotic selection before ureteral stent removal significantly reduced febrile pyelonephritis after radical cystectomy with intestinal urinary diversion, supporting its use as an effective infection prevention strategy in this high-risk population.

Indexed as

Antibiotic ProphylaxisCystectomyDevice RemovalFeverPostoperative ComplicationsPyelonephritisStentsUrinary Bladder NeoplasmsAgedFemaleHumansMaleMiddle AgedRetrospective StudiesUreterUrinary DiversionAntibiotic selectionAntimicrobial prophylaxisRadical cystectomyUreteral stent removalUrinary tract infection

Identifiers

PMID41848879
PMCPMC12999691

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.