Evidence map›Paper›PMID 41849099›Full record

ArticleMolecular diversity2026

Synthesis and anti-liver fibrotic activity study of a chalcone derivative through anti-inflammatory effects and inhibition of JNK/NF-κB signaling pathways.

Chunwei Lv, Lei Zhang, Chenxu Wang, Tingting Jin, Zhishun Zhang, Yixi Li, Dian He, Quanyi Zhao, Lifang Zheng

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunwei Lv *Institute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Lei Zhang *Gansu Medical Device Inspection and Testing Institute, Lanzhou, 730000, China.
Chenxu WangInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Tingting JinInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Zhishun ZhangInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Yixi LiInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Dian HeInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China. hed@lzu.edu.cn.
Quanyi ZhaoInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.
Lifang ZhengInstitute of Medicinal Chemistry, School of Pharmacy of Lanzhou University, Lanzhou, 730000, China.

Funding

Gansu Science and Technology Fund Grant 17ZD2FA009 and 18JR3RA417Lanzhou Science and Technology Bureau Program Funds 2021-1-141, 2021-RC-86National Science and Technology Ministry 2017ZX09101001
6 · The paper itself

Abstract

Liver fibrosis is a progressive disease caused by chronic inflammation and the activation of hepatic stellate cells (HSCs). This disease manifests as the abnormal proliferation and migration of HSCs, as well as the excessive deposition of the extracellular matrix. Chalcone analogues exhibit various biological activities, including anti-inflammatory, anti-proliferative, and apoptotic modulation properties, making them promising candidates for anti-fibrotic drug development. To enhance anti-fibrotic activities and decrease their side-effects, 31 novel chalcone derivatives were synthesized and evaluated. Among all the compounds, c31 exhibited the strongest anti-inflammatory activity, and its IC

Indexed as

Antifibrotic AgentsAnti-Inflammatory AgentsChalconeChalconesLiver CirrhosisMAP Kinase Signaling SystemNF-kappa BAnimalsApoptosisCarbon TetrachlorideCell LineCell MovementCell ProliferationHepatic Stellate CellsMaleRatsAntifibrotic AgentsAnti-Inflammatory AgentsCarbon TetrachlorideChalconeChalconesNF-kappa BChalcone derivativesHSC-T6InflammationJNK /NF-κB signaling pathwayLiver fibrosis

Identifiers

PMID41849099

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.