Evidence map›Paper›PMID 41849136›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Renal Functional Reserve and Its Association with eGFR Trajectories and Blood Pressure Patterns in Hypertensives with Preserved Renal Function.

Aikaterini Damianaki, Kyriakos Dimitriadis, Emelina Stambolliu, Panagiotis Iliakis, Dimitrios Konstantinidis, Konstantinos Tsioufis, Dimitrios Petras

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Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aikaterini DamianakiNephrology Department, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0000-0003-2815-3650
Kyriakos DimitriadisFirst Cardiology Clinic, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece. dimitriadiskyr@yahoo.gr.ORCID http://orcid.org/0000-0003-3186-8905
Emelina StambolliuNephrology Department, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0000-0002-3701-7004
Panagiotis IliakisFirst Cardiology Clinic, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0009-0004-5768-9125
Dimitrios KonstantinidisFirst Cardiology Clinic, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0000-0002-8843-6401
Konstantinos TsioufisFirst Cardiology Clinic, National and Kapodistrian University of Athens, Medical School, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0000-0002-7636-6725
Dimitrios PetrasNephrology Department, Hippokration Hospital, Athens, Greece.ORCID http://orcid.org/0000-0003-4469-094X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRenal Functional Reserve (RFR) is a promising marker for detecting early nephron loss and functional renal mass.

aimWe evaluated the relationship between RFR and changes in eGFR over time in hypertensive (HT) and normotensive (NT) individuals.

methodsIn this 24-month prospective study, newly diagnosed essential HT and NT individuals with eGFR ≥60 ml/min/1.73m

resultsA total of 51 HT and 20 NT subjects (mean age 53.2 ± 12.1 and 54.3 ± 10.0 years) completed the study. RFR levels did not differ between groups (25.1 ± 18.7 vs. 27.7 ± 15.7 ml/min, p = 0.6). No significant difference was found in the annual and the two-year eGFR change between HT and NT. At 24 months, HT and NT with RFR ≥30 ml/min showed less pronounced declines in eGFR compared to those with RFR <30 ml/min (0.5 ± 2.6 vs. - 1.4 ± 1.7 ml/min/1.73m

conclusionsRFR does not differ between HT and NT with preserved renal function but normal RFR is associated with slower eGFR decline. Reduced RFR correlates with non-dipping BP in HT.

Indexed as

Blood PressureEssential HypertensionGlomerular Filtration RateHypertensionKidneyAdultAgedBiomarkersBlood Pressure Monitoring, AmbulatoryCircadian RhythmCreatinineFemaleHumansMaleMiddle AgedProspective StudiesBiomarkersCreatinineCircadian rhythmGlomerular filtration rateHypertensionRenal functional reserve

Identifiers

PMID41849136
PMCPMC13222234

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.