ArticleGenes & genomics2026
Resolving repetitive and telomeric regions through a high-contiguity genome assembly of the African Turquoise killifish.
Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe turquoise killifish (Nothobranchius furzeri) is a powerful, short-lived vertebrate model for aging and evolutionary biology, characterized by rapid growth, high fecundity, and a distinctive life cycle. However, the existing reference genome has limitations in accurately resolving repetitive genomic regions and telomeric sequences.
objectiveIn this study, we present a high-quality genome assembly of the GRZ strain of the turquoise killifish (Nothobranchius furzeri), generated using high-fidelity long-read sequencing to provide a robust genomic resource for aging research. We assessed the assembly quality with a focus on repetitive elements, particularly the resolution of telomeric regions, as well as evolutionarily conserved genes and overall gene content.
methodsWe obtained high-fidelity (HiFi) long-read sequencing data using the PacBio Sequel2 platform to assemble the genome. To identify and remove contaminant sequences, taxonomic classification of scaffolds was performed. Genes of the genome were annotated with publicly available RNA sequencing data.
resultsCompared with the previously published reference (MPIA_NFZ_2.0), the current assembly showed markedly higher contiguity and improved resolution of repetitive sequences. These findings indicate that the larger genome size is largely attributable to the more complete representation of repetitive sequences. Notably, the recovery of the majority of telomeric sequences demonstrates a substantial advance in assembly completeness.
conclusionThis enhanced genome assembly provides a critical resource for advancing research on aging using the turquoise killifish model. The resulting high-contiguity genome assembly establishes a valuable reference resource that will accelerate genetic and genomic studies and enable deeper insights into phenotypic evolution in this species.
Indexed as
Identifiers
41849138What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.