ArticlePloS one2026
Trend of liver cancer attributable to alcohol use in China from 1992 to 2021: An age-period-cohort analysis study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
BACKGROUND &
aimsTo analyze the dynamic trends of mortality, incidence, and disability-adjusted life years (DALYs) of liver cancer attributable to alcohol use in China from 1992 to 2021, as well as the age, period, and cohort effects, so as to provide a basis for the prevention and control.
methodsThe data were sourced from the Global Burden of Disease Study 2021. The joinpoint regression model was used to assess the trend changes in mortality, incidence, and DALYs. The Age-Period-Cohort model was employed to estimate the independent effects of age, period, and cohort.
resultsFrom 1992 to 2021, the standardized incidence rate of liver cancer attributable to alcohol use in China increased annually by an average of 0.8% (95% CI: 0.5-1.1%), while the mortality rate rose by an average of 0.7% per year (95% CI: 0.3-1.0%), and the DALYs increased by an average of 0.6% annually (95% CI: 0.2-1.0%). The incidence and mortality rate ratio for men were approximately double those of women. The relative risk for individuals born between 1975 and 1985 increased 1.8-fold (95% CI: 1.5-2.1).
conclusionThe disease burden has been on a continuous upward trend, with middle-aged men identified as high-risk groups. It is recommended to integrate liver cancer screening into the health management for high-risk populations.
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