Evidence map›Paper›PMID 41849426›Full record

ArticleProtein & cell2026

RagC senses β-hydroxybutyrate abundancy to suppress mTORC1.

Guoyan Wang, Qihang Hou, Yong Zhang, Qiuhui Duan, Jianxuan Gao, Jiangxin Wang, Jinrui Qiao, Yining Zheng, Xinjian Lei, Guowen Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Guoyan WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Qihang HouCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.ORCID 0000-0002-0037-0402
Yong ZhangSenior Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Qiuhui DuanTongji University Cancer Center, Shanghai Tenth People's Hospital of Tongji University, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Jianxuan GaoDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.
Jiangxin WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Jinrui QiaoCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Yining ZhengCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xinjian LeiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Guowen LiuState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Lin LeiState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Tong MengDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China.
Xiaojun YangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Junhu YaoCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Xinwei LiState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
Lu DengCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.ORCID 0000-0002-3744-4102

Funding

National Natural Science Foundation of China 82472705National Natural Science Foundation of China U24A20454Shenzhen Natural Science Foundation in Basic Research Fund JCYJ20240813152007010
6 · The paper itself

Abstract

The ketogenic diet (KD), an emerging nutritional intervention for cancer, reprograms cellular energy metabolism from glucose to ketone bodies, including acetoacetate (AcAc), acetone (Ac), and β-hydroxybutyrate (BHB). However, the mechanisms connecting ketone body signal sensing to tumor growth suppression remain elusive. Here, we show that RagC, a key component of mTORC1 pathway, senses BHB but not AcAc and Ac, to dictate tumor suppression. KD-derived BHB inhibits mTORC1 activity by promoting β-hydroxybutyrylation (Kbhb) of RagC at lysine 349 (K348 in mice). Mechanistically, RagC-K349bhb is dynamically catalyzed by p300 and erased by SIRT1, disrupting RagC interaction with Raptor/mTOR and blocking mTORC1 recruitment to lysosomes. Clinically, BHB-mediated RagC-K349bhb suppresses colorectal cancer (CRC) growth via mTORC1 inhibition in both RagC-K348R knockin mice and CRC patient-derived samples. Thus, we identify a BHB sensing mechanism by mTORC1 and highlight the potential role of RagC-K349bhb as a therapeutic target for BHB-based CRC treatment.

Indexed as

3-Hydroxybutyric AcidColorectal NeoplasmsMechanistic Target of Rapamycin Complex 1AnimalsDiet, KetogenicHumansMiceRegulatory-Associated Protein of mTORSignal Transduction3-Hydroxybutyric AcidMechanistic Target of Rapamycin Complex 1Regulatory-Associated Protein of mTORmTORC1RagCtumor growthβ-hydroxybutyrylation

Identifiers

PMID41849426
PMCPMC13429462

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.