Evidence map›Paper›PMID 41849694›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

RENAL-CHIP: Rejection Evaluation via Non-Invasive Analysis of Circulating Podocytes With Herringbone-Chip Isolation Platform.

Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juan SongDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Yilong LiuKey Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province, The Ministry of Education Key Laboratory of Biopesticide and Chemical Biology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Zeyuan ZhengDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Ming ZhuDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Yuning ZouDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Pei LiuDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Yue ZhengDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Xiyuan YuDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Jianzhong ZhengDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Chen ShaoDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Huimin ZhangDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.
Chaoyong YangDiscipline of Intelligent Instrument and Equipment, College of Chemistry and Chemical Engineering, Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-2374-5342

Funding

National Key R&D Program of China 2024YFF1206600National Natural Science Foundation of China 22274066National Natural Science Foundation of China 82472737Scientific Research Foundation of State Key Laboratory of Vaccines for Infectious DiseasesXiamen Ocean and Fisheries Development Special Funds Program 22CZP006HJ03Xiang An Biomedicine Laboratory 2023XAKJ0100080
6 · The paper itself

Abstract

Immune rejection limits long-term renal allograft survival, yet current diagnostics lack non-invasive, and precise detection. Here, donor-derived circulating podocytes (CPCs) are identified as a blood-based surrogate of acute rejection. A magnetically reversible herringbone microfluidic chip equipped with epithelial cell adhesion molecule (EpCAM) antibody-functionalized magnetic beads efficiently isolates CPCs from 1 mL of peripheral blood (capture efficiency 84.4%, release 95.5%, viability 96.0%). Among 65 participants, only transplant recipients with biopsy-confirmed rejection exhibited≥35 CPCs mL

Indexed as

Graft RejectionKidney TransplantationLab-On-A-Chip DevicesPodocytesFemaleHumansIn Situ Hybridization, FluorescenceMalecirculating podocytesimmune rejectionmicrofluidic interfacenon‐invasive diagnosisrenal transplant

Identifiers

PMID41849694
PMCPMC13587950

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.