Evidence map›Paper›PMID 41850341›Full record

ArticleNeurobiology of disease2026

Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1.

Alyssa Soles, Jessica Grittner, Kaia Douglas, Praseuth Yang, Lisa Duvick, Brennon O'Callaghan, Ryan Barnett, Christine Chau, Roj Cosiquien, Orion Rainwater and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alyssa SolesDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Jessica GrittnerDivision of Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, 55455, USA.
Kaia DouglasDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Praseuth YangInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Lisa DuvickInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Brennon O'CallaghanInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Ryan BarnettDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Christine ChauDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Roj CosiquienDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Orion RainwaterInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Shannah SerresInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Brendan DoughertyDivision of Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: bdougher@umn.edu.
Harry T OrrInstitute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address: orrxx002@umn.edu.
Marija CvetanovicDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA; Institute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: mcvetano@umn.edu.

Funding

Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspectiveR35NS127248 · NINDS · UNIVERSITY OF MINNESOTA · PI Harry T. Orr · 2022 to 2026
$3.9M
Etiology of cognitive decline in Spinocerebellar ataxia type 1R01NS109077 · NINDS · UNIVERSITY OF MINNESOTA · PI Marija Cvetanovic, TIMOTHY J EBNER · 2020 to 2026
$2.4M
Understanding cellular and molecular mechanisms of neurodegenerationR01NS107387 · NINDS · UNIVERSITY OF MINNESOTA · PI CVETANOVIC, MARIJA · 2018 to 2021
$1.3M
NINDS NIH HHS R01 NS107387NINDS NIH HHS R01 NS109077NINDS NIH HHS R35 NS127248
6 · The paper itself

Abstract

Spinocerebellar ataxia type 1 is a neurodegenerative disease characterized by motor dysfunction and premature death usually from compromised swallowing and respiration. Using plethysmography, we characterized respiration in the conditional f-ATXN1

Indexed as

Ataxin-1Respiration DisordersSpinocerebellar AtaxiasAnimalsDisease Models, AnimalMiceMice, TransgenicMutationNeuronsRespirationAtaxin-1Atxn1 protein, mouseATXN1Breathing dysfunctionBulbar dysfunctionSCA1

Identifiers

PMID41850341
PMCPMC13134364

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.