Evidence map›Paper›PMID 41851067›Full record

ArticleGut microbes2026

A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.

Michele Biagioli, Cristina Di Giorgio, Silvia Marchianò, Benedetta Sensini, Ginevra Urbani, Eleonora Giannelli, Ginevra Lachi, Carmen Massa, Maria Rosaria Sette, Francesca Paniconi and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Michele BiagioliUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.ORCID 0000-0002-2995-6896
Cristina Di GiorgioUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.ORCID 0000-0001-7125-8963
Silvia MarchianòUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.ORCID 0000-0002-2488-9890
Benedetta SensiniUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Ginevra UrbaniUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Eleonora GiannelliUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Ginevra LachiUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Carmen MassaUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Maria Rosaria SetteUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Francesca PaniconiUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.
Elva MorrettaUniversity of Naples, Federico II, Pharmacy, Department of Pharmacy, Naples, Italy.
Maria Chiara MontiUniversity of Naples, Federico II, Pharmacy, Department of Pharmacy, Naples, Italy.
Angela ZampellaUniversity of Naples, Federico II, Pharmacy, Department of Pharmacy, Naples, Italy.ORCID 0000-0002-6170-279X
Eleonora DistruttiAzienda Ospedaliera di Perugia, SC di Gastroenterologia, Perugia, Italy.
Stefano FiorucciUniversity of Perugia, Medicine and Surgery, Department of Medicine and Surgery, Perugia, Italy.ORCID 0000-0003-3816-4222

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal fibrosis is a severe complication of Crohn's disease for which therapy remains suboptimal. Probiotics are widely used in the treatment of intestinal inflammation, but all major guidelines do not recommend in favor of their use, with the exception of an 8-strains bacterial formula, which is recommended for the treatment of pouch inflammation in ulcerative colitis. Using this 8-strains formulation as a comparator, we characterized a 9-strains probiotic formulation enriched with

Indexed as

Anti-Inflammatory AgentsBile Acids and SaltsColitisProbioticsReceptors, G-Protein-CoupledAnimalsDisease Models, AnimalFibrosisGastrointestinal MicrobiomeHumansLacticaseibacillus rhamnosusMaleMiceMice, Inbred C57BLMice, KnockoutAnti-Inflammatory AgentsBile Acids and SaltsGpbar1 protein, mouseReceptors, G-Protein-Coupled3-oxo-DCAGPBAR1IBDintestinal fibrosisprobioticSecondary bile acids

Identifiers

PMID41851067
PMCPMC13003854

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.