ArticleNature communications2026
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Predictive control of human pancreatic cell fate using a digital model ofbioRxiv : the preprint server for biology · 2026Article
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13 authors.
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Abstract
Knowledge of the molecular cues guiding pancreatic development is critical to developing beta cell replacement therapies for the treatment of diabetes. We compare different methods of pancreatic endocrine differentiation from human pluripotent stem cells (hPSCs) and establish sequences of patterning that can selectively increase the frequencies of islet-like or off-target enterochromaffin (EC)-like cells, thereby significantly increasing islet-like cellular yield and glucose-stimulated insulin secretion. Using a model of disrupted murine islet development that gives rise to pancreatic EC-like cells, we identify persistent Neurogenin 3 (NGN3) expression as a conserved feature associated with human and murine pancreatic EC-like cell differentiation. Finally, by comparing the phenotypes obtained through different patterning strategies, we observe that endocrine subtypes can vary significantly in their expression of canonical lineage markers. In addition to expanding our understanding of pancreatic endocrine lineage allocation and identity, these findings establish a logical differentiation framework to guide the generation of designer hPSC-islets for research and therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.