Evidence mapPaperPMID 41851749Full record

ReviewInflammation and regeneration2026

Immune molecular mechanisms of PANoptosis in sepsis-induced acute kidney injury.

Jie Zheng, Jian Lan, Ze-Yu Zhao, Liang Luo, Xi-Jiang Zhang, Qiong-Ying Hu

Abstract readReview
In one paragraph

Review in Inflammation and regeneration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jie Zheng *Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Jian Lan *Department of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Ze-Yu ZhaoDepartment of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Liang LuoDepartment of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Xi-Jiang ZhangDepartment of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China. zhangxijiang@foxmail.com.
Qiong-Ying HuDepartment of Critical Care Medicine, Taizhou Municipal Hospital (Taizhou University Affiliated Municipal Hospital), School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China. qiongyinghu@tzc.edu.cn.

Funding

the Huadong Medicine Joint Fund of the Zhejiang Provincial Natural Science Foundation of China LHDMY25H050002the Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project 2026ZL0149
6 · The paper itself

Abstract

Sepsis-induced acute kidney injury (S-AKI) is a common, life-threatening clinical complication with complex, incompletely understood pathophysiological mechanisms. Historically, the three main types of regulated cell death (RCD) were necroptosis, apoptosis, and pyroptosis. Recent discoveries of significant molecular overlap between these pathways have suggested that PANoptosis represents a combined inflammatory RCD mechanism. Accumulating evidence suggests that PANoptosis contributes to the progression of S-AKI. To clarify underlying mechanisms and guide innovative therapeutic methods, this review summarizes recent findings on the pathogenesis of S-AKI, with an emphasis on the growing significance of PANoptosis'.

Indexed as

Acute kidney injuryPANoptosisRegulated cell deathSepsis

Identifiers

PMID41851749
PMCPMC13045163

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.