SynthesisFrontiers in endocrinology2026
Traditional Chinese medicine for type 2 diabetes with metabolic-associated steatotic liver disease: unified effects and design thresholds.
Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Ferroptosis: A Novel Mechanism and Therapeutic Target of Traditional Chinese Medicine for Metabolic Dysfunction-Associated Steatotic Liver Disease.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to reorganize randomized controlled trials (RCTs) of traditional Chinese medicine (TCM) for adults with type 2 diabetes mellitus (T2DM) and metabolic-associated steatotic liver disease (MASLD; including legacy NAFLD) into a clinical evidence-anchored knowledge graph (KG) and harmonize effect semantics ("unified effects") to support endpoint- and design-aware evidence navigation. Methods: We systematically reviewed RCTs (2015-2025). Effect direction and scale were unified using a prespecified rule (treatment effect [TE] >0 indicates improvement). The prespecified primary endpoints maximizing cross-trial comparability were alanine aminotransferase (ALT), triglycerides (TG), Homeostatic Model Assessment of Insulin resistance (HOMA-IR), and controlled attenuation parameter (CAP); aspartate aminotransferase (AST) was retained for robustness. Metabolic endpoints were synthesized at the 12-week timepoint, while imaging endpoints (CAP and liver stiffness measurement [LSM]) were synthesized within a prespecified 8- to 24-week window. Trials were stratified as add-on versus mixed, with primary efficacy inferences based on add-on trials with balanced background Western medicine. Evidence was synthesized using REML-based random-effects meta-analysis (reporting prediction intervals) and weighted meta-regression. Risk of bias was assessed using RoB 2 and certainty of evidence using GRADE. Results: A total of 95 trials were included ( Conclusion: In adults with T2DM and MASLD, add-on trials show directionally favorable pooled biochemical/metabolic changes after unified effect harmonization, but uncertainty remains substantial. CAP may be a more reproducible short-term imaging endpoint than LSM. Evidence-derived design patterns should be interpreted as hypothesis-generating rather than causal thresholds. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251167450.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.