ArticleFrontiers in psychiatry2026
The mediating role of depressive symptoms in the relationship between obesity-related triglyceride-glucose index and cognitive status among middle-aged and elderly adults: a large cohort study.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent research suggests that the obesity-related triglyceride-glucose (TyG) index is associated with cognitive status and depressive symptoms. However, the existing evidence is limited and inconsistent. Furthermore, it remains unclear whether depressive symptoms play a significant role in the relationship between obesity-related TyG indexes and cognitive status. Objective: This study aims to investigate the relationship among the obesity-related TyG index, cognitive status, and depressive symptoms, as well as the role of depressive symptoms in the association between obesity-related TyG indexes and cognitive status. Methods: A total of 5,822 participants from the China Health and Retirement Longitudinal Study (CHARLS) were included in this study. Cognitive status was assessed using the Telephone Interview of Cognitive Status (TICS), while depressive symptoms were evaluated using the 10-item version of the Center for Epidemiologic Studies Depression Scale (CES-D-10). TyG and obesity-related indicators (body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR]) were calculated from individual blood and physical examinations. Multivariate linear regression was employed to examine the associations among the obesity-related TyG index, depressive symptoms, and cognitive status. Restricted cubic spline (RCS) analysis was used to test the non-linear relationships between the obesity-related TyG index and both cognitive status and depressive symptoms. Mediation analysis was conducted to assess the role of depressive symptoms in the relationship between the obesity-related TyG index and cognitive status. Results: The TyG-BMI (coefficient: 0.206; 95% confidence interval [ Conclusion: Depressive symptoms plays an important role in the relationship between both TyG-BMI and TyG-WC and cognitive status, highlighting depressive symptoms as a potentially relevant pathway that warrants further longitudinal and interventional validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.