ReviewADMET & DMPK2026
Schiff base metal complexes as emerging therapeutics against antimicrobial-resistant skin pathogens.
Review in ADMET & DMPK, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: The development of antimicrobial resistance reduces the efficacy of antimicrobial agents and poses a significant challenge to treat skin diseases. Many scientists, researchers, and pharmaceutical companies work diligently to investigate novel antimicrobial agents and discover alternatives to existing ones, aiming to address antimicrobial resistance. Within the broad field of metal complexes, Schiff base complexes occupy a prominent position, with structural versatility and significant biological properties that make them promising candidates for developing alternative drugs to combat the global crisis of antimicrobial resistance. Experimental approach: This paper reviewed the existing literature on how the structural features of some recently studied Schiff base ligands and their complexes influence the antibacterial and antifungal activities of these compounds against common skin pathogens, including Key results: The structural features, including the azomethine group (C=N), heteroatoms and substituents, in Schiff base compounds have been associated with interference with protein synthesis and the growth of bacterial and fungal cells. Schiff base compounds affect cell wall and cell membrane synthesis and inhibit enzymes essential to cell division and other cellular mechanisms. The chelation theory and the overtone's concept suggest that Schiff base metal complexes exhibit higher antibacterial and antifungal activities compared to Schiff base ligands. Conclusion: This review focuses on providing an overview of how the structural features of Schiff base compounds influence the antimicrobial properties of these compounds against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.