Evidence map›Paper›PMID 41853249›Full record

ArticleFrontiers in cell and developmental biology2026

NSMCE2 dispensability in mouse spermatogenesis suggests functional redundancy within the meiotic repair network.

Zihan Qin, Qiaohua Xiong, Mei Wang, Yuchen Fang, Qigang Fan, Binyu Ma, Ying Gao, Muyang Cheng, Yuming Cao, Yuanzhen Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zihan Qin *Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Qiaohua Xiong *Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Mei Wang *Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Yuchen FangCenter for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Qigang FanCenter for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Binyu MaCenter for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ying GaoCenter for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Muyang ChengDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Yuming CaoDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yuanzhen ZhangCenter for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NSMCE2, a SUMO E3 ligase subunit of the SMC5/6 complex, is essential for maintaining genomic integrity during mitosis, yet its meiotic function remains poorly understood. Here, we investigated the physiological role of NSMCE2 in male germ cells using a conditional knockout mouse model. Despite its high and stage-specific expression in testes, germline deletion of

Indexed as

functional redundancymale fertilitymeiosisNSMCE2spermatogenesis

Identifiers

PMID41853249
PMCPMC12992291

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.